MEWpy is an integrated Metabolic Engineering Workbench for strain design optimization. It offers methods to explore different classes of constraint-based models (CBM) for:
- Simulation: allows to simulate steady-state metabolic models, considering different formulations (e.g., GECKO, ETFL) and kinetic models;
- Optimization: performs Evolutionary Computation based strain design optimization by knocking out (KO) or over/under expressing (OU) reactions, genes, or enzymes.
- Omics data integration (eFlux, GIMME, iMAT);
- Regulatory networks integration (rFBA, srFBA)
MEWPy currently supports REFRAMED and COBRApy simulation environments.
For documentation and API please check: https://mewpy.readthedocs.io
pip install mewpy
Developed the Centre of Biological Engineering, University of Minho (2019-2023) and Vítor Pereira