granule.tem

// granule.tem
// Template for three-compartment granule cell model
// Andrew Davison, The Babraham Institute, 2000

begintemplate Gran
  public soma, periph, deep, AMPAr, NMDAr, spiketimes, spikecount
  create soma, periph, deep, s2d, s2p
  objref AMPAr, NMDAr, spiketimes, spikecount

  proc init() { local Len, Erest, RM, p, q, Atotal, gsp, gsd, AMPAtau, NMDAalpha, NMDAbeta, Erev, rsd, rsp
    create soma, periph, deep, s2d, s2p

    spiketimes = new Vector()
    lastspikecount = 0

    Erest		= -65		// mV
    Atotal		= 8353		// um2
    gsp			= 3.08e-10	// S/cm2
    gsd			= 4.34e-10
    RM			= 120000	// ohm.cm2
    Len			= 50
    p			= 0.0136
    q			= 0.308
    rsd 		= 1/(gsd*Atotal)
    rsp 		= 1/(gsp*Atotal)
    NMDAalpha		= 0.0163	// ms-1
    NMDAbeta		= 0.00292	// ms-1
    AMPAtau		= 5.5		// ms
    Erev		= 0		// mV

    soma {
      L 		= Len
      diam 		= p*Atotal/(PI*Len)
      Ra 		= PI/(4*Len*Atotal)
      insert pas
      e_pas 		= Erest		// reversal potential mV
      g_pas 		= 1/RM 		// membrane conductance S/cm2
      insert nagrantab
      insert kslowtab
      insert kM
      insert kA
      gnabar_nagrantab 	= 0.1611	// S/cm2
      gkbar_kslowtab 	= 0.1313
      gkbar_kM 		= 0.1334
      gkbar_kA 		= 0.0088
    }
    periph {
      L 		= Len
      diam 		= q*Atotal/(PI*Len)
      Ra 		= PI/(4*Len*Atotal)
      insert pas
      e_pas 		= Erest
      g_pas 		= 1/RM
      insert nagrantab
      insert kslowtab
      gnabar_nagrantab 	= 0.1355
      gkbar_kslowtab 	= 0.0243
      AMPAr = new ExpSyn(0.5)
      AMPAr.tau 	= AMPAtau
      AMPAr.e 		= Erev
      NMDAr = new NMDA(0.5)
      NMDAr.Alpha	= NMDAalpha
      NMDAr.Beta	= NMDAbeta
      NMDAr.e		= Erev
      spikecount = new APCount(0.5)
      spikecount.thresh = -30
      spikecount.record(spiketimes)
    }
    deep {
      L 		= Len
      diam 		= (1-p-q)*Atotal/(PI*Len)
      Ra 		= PI/(4*Len*Atotal)
      insert pas
      e_pas 		= Erest
      g_pas 		= 1/RM
    }
    s2d { 
      diam 		= 1
      Ra = PI*diam*diam/(4*Len*Atotal) * ( 1/gsd )
      L 		= 1
    }
    s2p { 
      diam 		= 1
      Ra = PI*diam*diam/(4*Len*Atotal) * ( 1/gsp )
      L 		= 1
    }

    soma connect s2p(0), 0
    s2p connect periph(0), 1
    soma connect s2d(0), 1
    s2d connect deep(0), 1

    // set reversal potentials, etc.
    forall if (ismembrane("na_ion")) {
      ena = 45	// mV
    }
    forall if (ismembrane("k_ion")) {
      ek  = -70	//  mV
    }

  }

endtemplate Gran