diff --git a/.github/compatibility-test-matrices/release-v5.0.x/upgrade.json b/.github/compatibility-test-matrices/release-v5.0.x/upgrade.json
new file mode 100644
index 00000000000..011a07ec0a9
--- /dev/null
+++ b/.github/compatibility-test-matrices/release-v5.0.x/upgrade.json
@@ -0,0 +1,12 @@
+{
+    "chain-a": ["v4.1.0", "v4.0.0"],
+    "chain-b": ["v4.1.0", "v4.0.0"],
+    "entrypoint": ["TestUpgradeTestSuite"],
+    "test": [
+      "TestV4ToV5ChainUpgrade"
+    ],
+    "chain-binary": ["simd"],
+    "chain-image": ["ghcr.io/cosmos/ibc-go-simd"],
+    "chain-upgrade-tag": ["v5.0.0"]
+  }
+  
\ No newline at end of file
diff --git a/.github/compatibility-test-matrices/release-v6.0.x/upgrade.json b/.github/compatibility-test-matrices/release-v6.0.x/upgrade.json
new file mode 100644
index 00000000000..69e17c90088
--- /dev/null
+++ b/.github/compatibility-test-matrices/release-v6.0.x/upgrade.json
@@ -0,0 +1,12 @@
+{
+    "chain-a": ["v0.3.5"],
+    "chain-b": ["v0.3.5"],
+    "entrypoint": ["TestUpgradeTestSuite"],
+    "test": [
+      "TestV5ToV6ChainUpgrade"
+    ],
+    "chain-binary": ["icad"],
+    "chain-image": ["ghcr.io/cosmos/ibc-go-icad"],
+    "chain-upgrade-tag": ["v0.4.0"]
+  }
+  
\ No newline at end of file
diff --git a/.github/workflows/e2e-compatibility-workflow-call.yaml b/.github/workflows/e2e-compatibility-workflow-call.yaml
index 9aa82416c69..e09271e87c0 100644
--- a/.github/workflows/e2e-compatibility-workflow-call.yaml
+++ b/.github/workflows/e2e-compatibility-workflow-call.yaml
@@ -47,4 +47,5 @@ jobs:
           CHAIN_A_TAG: "${{ matrix.chain-a }}"
           CHAIN_B_TAG: "${{ matrix.chain-b }}"
           CHAIN_BINARY: "${{ matrix.chain-binary }}"
+          CHAIN_UPGRADE_TAG: "${{ matrix.chain-upgrade-tag }}"
           RLY_TAG: "v2.0.0"
diff --git a/.github/workflows/e2e-compatibility.yaml b/.github/workflows/e2e-compatibility.yaml
index 5960e5a27e7..7c64021f5b9 100644
--- a/.github/workflows/e2e-compatibility.yaml
+++ b/.github/workflows/e2e-compatibility.yaml
@@ -75,3 +75,12 @@ jobs:
     with:
       docker-tag: "${{ needs.determine-docker-tag.outputs.docker-tag }}"
       test-suite: "incentivized-transfer"
+
+  upgrade:
+    needs:
+      - build-release-image
+      - determine-docker-tag
+    uses: ./.github/workflows/e2e-compatibility-workflow-call.yaml
+    with:
+      docker-tag: "${{ needs.determine-docker-tag.outputs.docker-tag }}"
+      test-suite: "upgrade"