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<!DOCTYPE HTML>
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<title>Elzbieta Gralinska</title>
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<h1>Elzbieta Gralinska</h1>
<p>computational biologist passionate about searching for<br />
clues in clinical data.</p>
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<li><a href="#intro">Intro</a></li>
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<h2 class="major">Intro</h2>
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<h4 class="major">Elzbieta Gralinska, Dr. rer. nat.</h4>
<p>
Computational Biologist & Data Scientist </p>
<p> Research focus:
<ul>
<li> Clinical biomarkers </li>
<li> Multi-omics data </li>
<li> High-dimensional data projection methods </li>
<li> Molecular interaction networks</li>
</ul>
</p>
<p>In 2022 I received a Dr. rer. nat. title (PhD) in Bioinformatics from the Max Planck Institute for Molecular Genetics. In my doctoral project, under the supervision of Martin Vingron, we focused on developing a method for identification of cluster-specific genes from high-dimensional transcriptomics data. You can learn more about our project from the <a href="https://www.molgen.mpg.de/4521263/news_publication_18911881_transferred?c=228720">press release</a> of MPIMG. An R package, implementing our method, is available on <a href="https://bioconductor.org/packages/release/bioc/html/APL.html">Bioconductor</a>.</p>
<p>Currently, I am working as a postdoctoral scientist at Roche, focusing on biomarkers and cancer immunotherapies. </p>
</article>
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<h2 class="major">Bio</h2>
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<h3 class="major">Research experience</h3>
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<b>Roche</b>
<h4>2023 - ongoing: Postdoctoral Scientist</h4>
<p>
Roche Pharma Research & Early Development (pRED)
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<b>Max Planck Institute for Molecular Genetics</b>
<h4>2022: Postdoctoral Researcher</h4>
<h4>2017 - 2022: PhD Candidate</h4>
<p>
Department of Computational Molecular Biology, <br />
Transcriptional Regulation Group <br />
Supervision: Martin Vingron
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<b> University of Lausanne </b>
<h4>02 - 04.2017: Research Intern</h4>
<p>
Computational Cancer Biology Group <br />
Supervision: David Gfeller
</p>
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<b>Max Planck Institute for Molecular Genetics</b>
<h4>2015 - 2016: Student Assistant</h4>
<p>
Molecular Interaction Network Group <br />
Supervision: Ulrich Stelzl
</p>
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<b>Central Forensic Laboratory of the Police</b>
<h4>08 - 09.2015: Summer Intern</h4>
<p>
Department of Biology
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<b>German Rheumatism Research Centre Berlin (DRFZ)</b>
<h4>2014 - 2015: Student Assistant</h4>
<p>
Signal Transduction Group <br />
Supervision: Ria Baumgrass
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<h3 class="major">Education</h3>
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<b>2017 – 2022: PhD in Bioinformatics</b>
<h5>Freie Universität Berlin & International Max Planck Research School for Biology And Computation (IMPRS-BAC) </h5>
<p>
Thesis title: “Association Plots visualize cluster-specific genes from high-dimensional transcriptomics data” <br />
Supervision: Prof. Dr. Martin Vingron (MPIMG)
</p>
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<b>2015 – 2016: Master of Science in Biotechnology</b>
<h5>Technische Universität Berlin</h5>
<p>
Thesis title: “Tissue-specific network analysis of RNA-binding protein interactions”<br />
Supervision: Prof. Dr. Ulrich Stelzl (MPIMG)
</p>
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<b>2013 – 2015: Bachelor of Science in Biotechnology</b>
<h5>Technische Universität Berlin</h5>
<p>
Thesis title: “The construction of a transcription factor network for Th2 cells by integration of global gene expression and DNA-binding data” <br />
Supervision: Prof. Dr. Ria Baumgrass (DRFZ)
</p>
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<b>2012 – 2013: Inter-Faculty Individual Studies in Mathematics and Natural Sciences</b>
<h5>University of Warsaw</h5>
<p>
Specialization: Mathematics, Biotechnology
</p>
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</article>
<!-- About -->
<article id="papers">
<h2 class="major">Publications</h2>
<span class="image main"><img src="images/AP.JPG" alt="" /></span>
<h3 class="major">Papers</h3>
<p>
<ol type="1">
<li>Bebelman M<sup>*</sup>, Belicova L<sup>*</sup>, <b>Gralinska E</b>, Jumel T, Lahree A, Sommer S, Shevchenko A, Zatsepin T, Kalaidzidis Y, Vingron M, Zerial M. Hepatocyte differentiation requires anisotropic expansion of bile canaliculi. <i>Development</i> (2024). doi: 10.1242/dev.202777. (<a href="https://journals.biologists.com/dev/article/doi/10.1242/dev.202777/362269">link</a>)</li>
<li>van der Weijden V, Stötzel M, Iyer D, Fauler B, <b>Gralinska E</b>, Shahraz M, Meierhofer D, Vingron M, Rulands S, Alexandrov T, Mielke T, Bulut-Karslioglu A. FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. <i>Nature Cell Biology</i> (2024). doi: 10.1038/s41556-023-01325-3. (<a href="https://www.nature.com/articles/s41556-023-01325-3">link</a>)</li>
<li><b>Gralinska E</b> and Vingron M. Association Plots: visualizing cluster-specific associations in high-dimensional correspondence analysis biplots. <i>Journal of the Royal Statistical Society Series C: Applied Statistics</i> (2023). doi: 10.1093/jrsssc/qlad039. (<a href="https://academic.oup.com/jrsssc/advance-article/doi/10.1093/jrsssc/qlad039/7192360">link</a>)</li>
<li>Rosebrock D<sup>*</sup>, Arora S<sup>*</sup>, Mutukula N, Volkman R, <b>Gralinska E</b>, Balaskas A, Aragonés Hernández A, Buschow R, Brändl B, Müller FJ, Arndt PF, Vingron M and Elkabetz Y. Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells. <i>Nature Cell Biol</i> (2022). doi: 10.1038/s41556-022-00929-5. (<a href="https://www.nature.com/articles/s41556-022-00929-5">link</a>)</li>
<li><b>Gralinska E</b>, Kohl C, Sokhandan Fadakar B, Vingron M. Visualizing cluster-specific genes from single-cell transcriptomics data using Association Plots. <i>JMB</i>. 2022, 434(11), 167525. (<a href="https://www.sciencedirect.com/science/article/pii/S0022283622000997">link</a>)</li>
<li>Belicova L, Repnik U, Delpierre J, <b>Gralinska E</b>, Seifert S, Ignacio Valenzuela J, Morales-Navarrete HA, Franke C, Räägel H, Shcherbinina E, Prikazchikova T, Koteliansky V, Vingron M, Kalaidzidis YL, Zatsepin T, Zerial M. Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads. <i>J Cell Biol</i>. 2021 Oct 4;220(10):e202103003. doi: 10.1083/jcb.202103003. (<a href="https://rupress.org/jcb/article/220/10/e202103003/212522/Anisotropic-expansion-of-hepatocyte-lumina">link</a>)</li>
<li>Jargosch M, Kröger S, <b>Gralinska E</b>, Klotz U, Fang Z, Chen W, Leser U, Selbig J, Groth D, Baumgrass R. Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions. <i>Genet Mol Res</i>. 2016 Jun 24;15(2). doi: 10.4238/gmr.15028493. (<a href="https://pubmed.ncbi.nlm.nih.gov/27420972/">link</a>)</li>
</ol>
</p>
<p>
<sup>*</sup>These authors contributed equally.
</p>
<h3 class="major">Theses</h3>
<p>
<ul>
<li><b>Elzbieta Gralinska</b>, "Association Plots visualize cluster-specific genes from high-dimensional transcriptomics data"</q>, PhD thesis, Freie Universität Berlin. 2022</li>
<li><b>Elzbieta Gralinska</b>, "Tissue-specific network analysis of RNA-binding protein interactions"</q>, Master thesis, Technische Universität Berlin. 2016</li>
<li><b>Elzbieta Gralinska</b>, "The construction of a transcription factor network for Th2 cells by integration of global gene expression and DNA-binding data"</q>, Bachelor thesis, Technische Universität Berlin. 2015</li>
</ul>
</p>
</article>
<!-- After work -->
<article id="after">
<h2 class="major">After work</h2>
<p>
Science-related topics are very close to my heart. That’s why in my free time I’m also involved in various activities and projects focusing on science promotion and communication. If you want to hear more, please don’t hesitate to reach out to me.
<p>
<ul>
<li><b>Young European Biotech Network e.V.</b> <br />
YEBN e.V is a non-profit organization that focuses on building a bridge between academia and industry. As an Executive Board member, since 2020 I am actively participating in the life of YEBN e.V. In the Executive Board I am mainly involved in the administrative tasks of our organisation.</li>
<li><b>Science diplomacy</b> <br />
My adventure with science diplomacy began relatively recently, when I had a pleasure to become the member of the <a href="https://responsibility.igem.org/opportunities/biodiversity202"> iGEM Youth Biodiversity Leadership Program 2022 </a>, an initiative which aims to gather together iGEMers who are concerned about global biodiversity and which consists of training sessions in diplomacy and governance. <br />
I’ve also had a pleasure to receive an invitation to the “Responsibility Conference: Navigating the Future of Synthetic Biology”. The conference took place on October 26-27, 2022, in Paris, as a partner event of the iGEM (International Genetically Engineered Machine) <a href="https://jamboree.igem.org/2022"> Grand Jamboree </a>. <br />
Recently I was also selected as a member of the <a href="https://research-and-innovation.ec.europa.eu/news/all-research-and-innovation-news/launch-eu-science-diplomacy-working-groups-results-call-expressions-interest-published-2023-12-06_en"> EU Science Diplomacy Working Group 2 </a>: "making European diplomacy more strategic, effective and resilient through scientific evidence and foresight", launched by the European Commission. The working groups are composed of experts from both the science and diplomacy communities. The main goal of the created working groups is to develop jointly a set of recommendations that will help to develope future European framework for science diplomacy.</li>
<li><b>Science communication</b> <br />
Communicating science to non-scientists is of high importance, especially in the times of pandemic and growing anti-vaccine movements. I am especially interested in recording short sci-com videos and building a community of science enthusiasts. I am also the co-author of the book “Biologia Syntetyczna - Możliwości i Wyzwania” (“Synthetic Biology - Opportunities and Challenges”). The book was published by the Polish Ministry of Science and Higher Education in cooperation with the Copernicus Science Center in Warsaw (2015).</li>
</ul>
</p>
</article>
<!-- Contact -->
<article id="contact">
<h2 class="major">Contact</h2>
<p>
For questions and comments please message me via <a href="https://linkedin.com/in/ela-gralinska">LinkedIn</a>.
</p>
<ul class="icons">
<li><a href="https://linkedin.com/in/ela-gralinska" class="icon brands fa-linkedin"><span class="label">LinkedIn</span></a></li>
<li><a href="https://twitter.com/ela_gralinska" class="icon brands fa-twitter"><span class="label">Twitter</span></a></li>
</ul>
</article>
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<h2 class="major">Elements</h2>
<section>
<h3 class="major">Text</h3>
<p>This is <b>bold</b> and this is <strong>strong</strong>. This is <i>italic</i> and this is <em>emphasized</em>.
This is <sup>superscript</sup> text and this is <sub>subscript</sub> text.
This is <u>underlined</u> and this is code: <code>for (;;) { ... }</code>. Finally, <a href="#">this is a link</a>.</p>
<hr />
<h2>Heading Level 2</h2>
<h3>Heading Level 3</h3>
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<h6>Heading Level 6</h6>
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<h4>Blockquote</h4>
<blockquote>Fringilla nisl. Donec accumsan interdum nisi, quis tincidunt felis sagittis eget tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan faucibus. Vestibulum ante ipsum primis in faucibus lorem ipsum dolor sit amet nullam adipiscing eu felis.</blockquote>
<h4>Preformatted</h4>
<pre><code>i = 0;
while (!deck.isInOrder()) {
print 'Iteration ' + i;
deck.shuffle();
i++;
}
print 'It took ' + i + ' iterations to sort the deck.';</code></pre>
</section>
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<h3 class="major">Lists</h3>
<h4>Unordered</h4>
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<li>Dolor pulvinar etiam.</li>
<li>Sagittis adipiscing.</li>
<li>Felis enim feugiat.</li>
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<li>Sagittis adipiscing.</li>
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<li>Dolor pulvinar etiam.</li>
<li>Etiam vel felis lorem.</li>
<li>Felis enim et feugiat.</li>
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<li><a href="#" class="icon brands fa-twitter"><span class="label">Twitter</span></a></li>
<li><a href="#" class="icon brands fa-facebook-f"><span class="label">Facebook</span></a></li>
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<li><a href="#" class="icon brands fa-github"><span class="label">Github</span></a></li>
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<td>Item One</td>
<td>Ante turpis integer aliquet porttitor.</td>
<td>29.99</td>
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<td>Item Two</td>
<td>Vis ac commodo adipiscing arcu aliquet.</td>
<td>19.99</td>
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<td>Item Three</td>
<td> Morbi faucibus arcu accumsan lorem.</td>
<td>29.99</td>
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<td>Vitae integer tempus condimentum.</td>
<td>19.99</td>
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<td>Ante turpis integer aliquet porttitor.</td>
<td>29.99</td>
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<td>29.99</td>
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<tr>
<td>Item Two</td>
<td>Vis ac commodo adipiscing arcu aliquet.</td>
<td>19.99</td>
</tr>
<tr>
<td>Item Three</td>
<td> Morbi faucibus arcu accumsan lorem.</td>
<td>29.99</td>
</tr>
<tr>
<td>Item Four</td>
<td>Vitae integer tempus condimentum.</td>
<td>19.99</td>
</tr>
<tr>
<td>Item Five</td>
<td>Ante turpis integer aliquet porttitor.</td>
<td>29.99</td>
</tr>
</tbody>
<tfoot>
<tr>
<td colspan="2"></td>
<td>100.00</td>
</tr>
</tfoot>
</table>
</div>
</section>
<section>
<h3 class="major">Buttons</h3>
<ul class="actions">
<li><a href="#" class="button primary">Primary</a></li>
<li><a href="#" class="button">Default</a></li>
</ul>
<ul class="actions">
<li><a href="#" class="button">Default</a></li>
<li><a href="#" class="button small">Small</a></li>
</ul>
<ul class="actions">
<li><a href="#" class="button primary icon solid fa-download">Icon</a></li>
<li><a href="#" class="button icon solid fa-download">Icon</a></li>
</ul>
<ul class="actions">
<li><span class="button primary disabled">Disabled</span></li>
<li><span class="button disabled">Disabled</span></li>
</ul>
</section>
<section>
<h3 class="major">Form</h3>
<form method="post" action="#">
<div class="fields">
<div class="field half">
<label for="demo-name">Name</label>
<input type="text" name="demo-name" id="demo-name" value="" placeholder="Jane Doe" />
</div>
<div class="field half">
<label for="demo-email">Email</label>
<input type="email" name="demo-email" id="demo-email" value="" placeholder="gralinska@molgen.mpg.de" />
</div>
<div class="field">
<label for="demo-category">Category</label>
<select name="demo-category" id="demo-category">
<option value="">-</option>
<option value="1">Manufacturing</option>
<option value="1">Shipping</option>
<option value="1">Administration</option>
<option value="1">Human Resources</option>
</select>
</div>
<div class="field half">
<input type="radio" id="demo-priority-low" name="demo-priority" checked>
<label for="demo-priority-low">Low</label>
</div>
<div class="field half">
<input type="radio" id="demo-priority-high" name="demo-priority">
<label for="demo-priority-high">High</label>
</div>
<div class="field half">
<input type="checkbox" id="demo-copy" name="demo-copy">
<label for="demo-copy">Email me a copy</label>
</div>
<div class="field half">
<input type="checkbox" id="demo-human" name="demo-human" checked>
<label for="demo-human">Not a robot</label>
</div>
<div class="field">
<label for="demo-message">Message</label>
<textarea name="demo-message" id="demo-message" placeholder="Enter your message" rows="6"></textarea>
</div>
</div>
<ul class="actions">
<li><input type="submit" value="Send Message" class="primary" /></li>
<li><input type="reset" value="Reset" /></li>
</ul>
</form>
</section>
</article>
</div>
<!-- Footer -->
<footer id="footer">
<p class="copyright">© Untitled. Design: <a href="https://html5up.net">HTML5 UP</a>.</p>
</footer>
</div>
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<div id="bg"></div>
<!-- Scripts -->
<script src="assets/js/jquery.min.js"></script>
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