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original paper: Guo et al.
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general pros/cons of RRBS apply:
- low coverage of regions with little CpG density
- generally sparse representation: ca. 1 mio CpGsv(1-10% of all CpGs)
- improved detection of promoter/CpG-rich regions
- relatively consistent across replicates
DeepCpG can be used to impute missing values to get a more granular picture at the single-cell level Angermueller et al., 2017