diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8a800b1..8ea56e3 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -5,6 +5,9 @@ The format is based on [Keep a Changelog](http://keepachangelog.com/en/1.0.0/)
 and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0.html).
 
 ## [unreleased]
+### ...
+
+## [1.4.5]
 ### Fixed
 - Fixed issue with new interaction type labeling system.
 
@@ -14,6 +17,7 @@ and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0.
 ### Changed
 - Separated curve calculation and fraction calculation to different functions.
 - Harmonized `melt_X.py` scripts output.
+- Better fasta reading management: not kept in memory and considering sequences with same header as separate fasta items.
 
 ### Added
 - `plot_melt_curves_coupled.R` for single-oligo coupled melting curve plot.
@@ -71,6 +75,7 @@ and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0.
 ## [1.0.0]
 
 * [unreleased] https://github.com/ggirelli/oligo-melting
+* [1.4.5] https://github.com/ggirelli/oligo-melting/releases/tag/v1.4.5
 * [1.4.4] https://github.com/ggirelli/oligo-melting/releases/tag/v1.4.4
 * [1.4.3] https://github.com/ggirelli/oligo-melting/releases/tag/v1.4.3
 * [1.4.2] https://github.com/ggirelli/oligo-melting/releases/tag/v1.4.2
diff --git a/lib/__pycache__/meltlib.cpython-36.pyc b/lib/__pycache__/meltlib.cpython-36.pyc
index 2a20ffd..cc72a01 100644
Binary files a/lib/__pycache__/meltlib.cpython-36.pyc and b/lib/__pycache__/meltlib.cpython-36.pyc differ
diff --git a/melt_duplex.py b/melt_duplex.py
index 92ebe32..2e75b8a 100755
--- a/melt_duplex.py
+++ b/melt_duplex.py
@@ -227,28 +227,30 @@
     data['seq'] = seq
     duMelt_calc(**data)
 else:
-    # Empty sequence dictionary
-    fastad = {}
+    if not is_verbose:
+        print("oligo_name\tdG\tdH\tdS\tTm\tSeq")
 
     # Input file case
     curr_head = ""
+    curr_seq = ""
     with open(seq) as fin:
         for row in fin:
             if ">" == row[0]:
+                if not 0 == len(curr_seq) and not 0 == len(curr_head):
+                    # Calculate before moving to the next item
+                    data['name'] = curr_head
+                    data['seq'] = curr_seq
+                    duMelt_calc(**data)
+
                 curr_head = row[1:].strip()
+                curr_seq = ""
             else:
-                if curr_head in fastad.keys():
-                    fastad[curr_head] = fastad[curr_head] + row.strip()
-                else:
-                    fastad[curr_head] = row.strip()
+                curr_seq += row.strip()
 
-    # Calculate for each fasta item
-    if not is_verbose:
-        print("oligo_name\tdG\tdH\tdS\tTm\tSeq")
-    for (name, seq) in fastad.items():
-        data['name'] = name
-        data['seq'] = seq
-        duMelt_calc(**data)
+    # Calculate for last item
+    data['name'] = curr_head
+    data['seq'] = curr_seq
+    duMelt_calc(**data)
 
 # END ==========================================================================