diff --git a/contrib/drivers/mysql/mysql_z_unit_issue_test.go b/contrib/drivers/mysql/mysql_z_unit_issue_test.go
index ff4dd70d5bd..7750606308d 100644
--- a/contrib/drivers/mysql/mysql_z_unit_issue_test.go
+++ b/contrib/drivers/mysql/mysql_z_unit_issue_test.go
@@ -1091,3 +1091,37 @@ func Test_Issue2552_ClearTableFields(t *testing.T) {
 		t.Assert(gstr.Contains(gstr.Join(sqlArray, "|"), showTableKey), true)
 	})
 }
+
+// https://github.com/gogf/gf/issues/2643
+func Test_Issue2643(t *testing.T) {
+	table := "issue2643"
+	array := gstr.SplitAndTrim(gtest.DataContent(`issue2643.sql`), ";")
+	for _, v := range array {
+		if _, err := db.Exec(ctx, v); err != nil {
+			gtest.Error(err)
+		}
+	}
+	defer dropTable(table)
+
+	gtest.C(t, func(t *gtest.T) {
+		var (
+			expectKey1 = "SELECT s.name,replace(concat_ws(',',lpad(s.id, 6, '0'),s.name),',','') `code` FROM `issue2643` AS s"
+			expectKey2 = "SELECT CASE WHEN dept='物资部' THEN '物资部' ELSE '其他' END dept,sum(s.value) FROM `issue2643` AS s GROUP BY CASE WHEN dept='物资部' THEN '物资部' ELSE '其他' END"
+		)
+		sqlArray, err := gdb.CatchSQL(ctx, func(ctx context.Context) error {
+			db.Ctx(ctx).Model(table).As("s").Fields(
+				"s.name",
+				"replace(concat_ws(',',lpad(s.id, 6, '0'),s.name),',','') `code`",
+			).All()
+			db.Ctx(ctx).Model(table).As("s").Fields(
+				"CASE WHEN dept='物资部' THEN '物资部' ELSE '其他' END dept",
+				"sum(s.value)",
+			).Group("CASE WHEN dept='物资部' THEN '物资部' ELSE '其他' END").All()
+			return nil
+		})
+		t.AssertNil(err)
+		sqlContent := gstr.Join(sqlArray, "\n")
+		t.Assert(gstr.Contains(sqlContent, expectKey1), true)
+		t.Assert(gstr.Contains(sqlContent, expectKey2), true)
+	})
+}
diff --git a/contrib/drivers/mysql/mysql_z_unit_model_test.go b/contrib/drivers/mysql/mysql_z_unit_model_test.go
index 1a2c7e1f152..5d01841d062 100644
--- a/contrib/drivers/mysql/mysql_z_unit_model_test.go
+++ b/contrib/drivers/mysql/mysql_z_unit_model_test.go
@@ -2286,7 +2286,7 @@ func Test_Model_Option_Where(t *testing.T) {
 		n, _ := r.RowsAffected()
 		t.Assert(n, TableSize)
 	})
-	return
+
 	gtest.C(t, func(t *gtest.T) {
 		table := createInitTable()
 		defer dropTable(table)
diff --git a/contrib/drivers/mysql/testdata/issue2643.sql b/contrib/drivers/mysql/testdata/issue2643.sql
new file mode 100644
index 00000000000..8b293402dae
--- /dev/null
+++ b/contrib/drivers/mysql/testdata/issue2643.sql
@@ -0,0 +1,7 @@
+CREATE TABLE `issue2643` (
+    `id` INT(10) NULL DEFAULT NULL,
+    `name` VARCHAR(50) NULL DEFAULT NULL COLLATE 'utf8mb4_0900_ai_ci',
+    `value` INT(10) NULL DEFAULT NULL,
+    `dept` VARCHAR(50) NULL DEFAULT NULL COLLATE 'utf8mb4_0900_ai_ci'
+)
+COLLATE='utf8mb4_0900_ai_ci' ENGINE=InnoDB
\ No newline at end of file
diff --git a/database/gdb/gdb.go b/database/gdb/gdb.go
index e0ddc0329bc..f1caf4fee68 100644
--- a/database/gdb/gdb.go
+++ b/database/gdb/gdb.go
@@ -494,6 +494,10 @@ var (
 	// which is a regular field name of table.
 	regularFieldNameRegPattern = `^[\w\.\-]+$`
 
+	// regularFieldNameWithCommaRegPattern is the regular expression pattern for one or more strings
+	// which are regular field names of table, multiple field names joined with char ','.
+	regularFieldNameWithCommaRegPattern = `^[\w\.\-,\s]+$`
+
 	// regularFieldNameWithoutDotRegPattern is similar to regularFieldNameRegPattern but not allows '.'.
 	// Note that, although some databases allow char '.' in the field name, but it here does not allow '.'
 	// in the field name as it conflicts with "db.table.field" pattern in SOME situations.
diff --git a/database/gdb/gdb_core.go b/database/gdb/gdb_core.go
index 556318d6a4e..4283030e8eb 100644
--- a/database/gdb/gdb_core.go
+++ b/database/gdb/gdb_core.go
@@ -767,6 +767,8 @@ func (c *Core) HasTable(name string) (bool, error) {
 	if err != nil {
 		return false, err
 	}
+	charL, charR := c.db.GetChars()
+	name = gstr.Trim(name, charL+charR)
 	for _, table := range tables {
 		if table == name {
 			return true, nil
diff --git a/database/gdb/gdb_core_utility.go b/database/gdb/gdb_core_utility.go
index 1e24e0e613e..71f0b48ea8a 100644
--- a/database/gdb/gdb_core_utility.go
+++ b/database/gdb/gdb_core_utility.go
@@ -93,6 +93,9 @@ func (c *Core) QuoteWord(s string) string {
 //
 // The meaning of a `string` can be considered as part of a statement string including columns.
 func (c *Core) QuoteString(s string) string {
+	if !gregex.IsMatchString(regularFieldNameWithCommaRegPattern, s) {
+		return s
+	}
 	charLeft, charRight := c.db.GetChars()
 	return doQuoteString(s, charLeft, charRight)
 }
diff --git a/database/gdb/gdb_model_utility.go b/database/gdb/gdb_model_utility.go
index 0873af25f2c..9a5da85225e 100644
--- a/database/gdb/gdb_model_utility.go
+++ b/database/gdb/gdb_model_utility.go
@@ -68,30 +68,40 @@ func (m *Model) mappingAndFilterToTableFields(table string, fields []string, fil
 	if len(fieldsMap) == 0 {
 		return fields
 	}
-	var (
-		inputFieldsArray  = gstr.SplitAndTrim(gstr.Join(fields, ","), ",")
-		outputFieldsArray = make([]string, 0, len(inputFieldsArray))
-	)
+	var outputFieldsArray = make([]string, 0)
 	fieldsKeyMap := make(map[string]interface{}, len(fieldsMap))
 	for k := range fieldsMap {
 		fieldsKeyMap[k] = nil
 	}
-	for _, field := range inputFieldsArray {
-		if _, ok := fieldsKeyMap[field]; !ok {
-			if !gregex.IsMatchString(regularFieldNameWithoutDotRegPattern, field) {
-				// Eg: user.id, user.name
-				outputFieldsArray = append(outputFieldsArray, field)
+	for _, field := range fields {
+		var inputFieldsArray []string
+		if gregex.IsMatchString(regularFieldNameWithoutDotRegPattern, field) {
+			inputFieldsArray = append(inputFieldsArray, field)
+		} else if gregex.IsMatchString(regularFieldNameWithCommaRegPattern, field) {
+			inputFieldsArray = gstr.SplitAndTrim(field, ",")
+		} else {
+			// Example:
+			// user.id, user.name
+			// replace(concat_ws(',',lpad(s.id, 6, '0'),s.name),',','') `code`
+			outputFieldsArray = append(outputFieldsArray, field)
+			continue
+		}
+		for _, inputField := range inputFieldsArray {
+			if !gregex.IsMatchString(regularFieldNameWithoutDotRegPattern, inputField) {
+				outputFieldsArray = append(outputFieldsArray, inputField)
 				continue
-			} else {
-				// Eg: id, name
-				if foundKey, _ := gutil.MapPossibleItemByKey(fieldsKeyMap, field); foundKey != "" {
+			}
+			if _, ok := fieldsKeyMap[inputField]; !ok {
+				// Example:
+				// id, name
+				if foundKey, _ := gutil.MapPossibleItemByKey(fieldsKeyMap, inputField); foundKey != "" {
 					outputFieldsArray = append(outputFieldsArray, foundKey)
 				} else if !filter {
-					outputFieldsArray = append(outputFieldsArray, field)
+					outputFieldsArray = append(outputFieldsArray, inputField)
 				}
+			} else {
+				outputFieldsArray = append(outputFieldsArray, inputField)
 			}
-		} else {
-			outputFieldsArray = append(outputFieldsArray, field)
 		}
 	}
 	return outputFieldsArray