diff --git a/CHANGELOG.md b/CHANGELOG.md
index 985fea97acb6a..2b9fc397ef83f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -50,6 +50,7 @@
 ##### Fixes
 
 * [10631](https://github.com/grafana/loki/pull/10631) **thampiotr**: Fix race condition in cleaning up metrics when stopping to tail files.
+* [10798](https://github.com/grafana/loki/pull/10798) **hainenber**: Fix agent panicking after reloaded due to duplicate metric collector registration.
 
 #### LogCLI
 
diff --git a/clients/pkg/promtail/targets/lokipush/pushtarget.go b/clients/pkg/promtail/targets/lokipush/pushtarget.go
index a204227df529b..7bd63e47d6de0 100644
--- a/clients/pkg/promtail/targets/lokipush/pushtarget.go
+++ b/clients/pkg/promtail/targets/lokipush/pushtarget.go
@@ -82,6 +82,12 @@ func (t *PushTarget) run() error {
 	serverCfg := &t.config.Server
 	serverCfg.Log = util_log.InitLogger(serverCfg, prometheus.NewRegistry(), true, false)
 
+	// Set new registry for upcoming metric server
+	// If not, it'll likely panic when the tool gets reloaded.
+	if t.config.Server.Registerer == nil {
+		t.config.Server.Registerer = prometheus.NewRegistry()
+	}
+
 	srv, err := server.New(t.config.Server)
 	if err != nil {
 		return err
diff --git a/clients/pkg/promtail/wal/watcher_metrics.go b/clients/pkg/promtail/wal/watcher_metrics.go
index 34b74786e15b9..7fd15c7af2306 100644
--- a/clients/pkg/promtail/wal/watcher_metrics.go
+++ b/clients/pkg/promtail/wal/watcher_metrics.go
@@ -1,6 +1,10 @@
 package wal
 
-import "github.com/prometheus/client_golang/prometheus"
+import (
+	"errors"
+
+	"github.com/prometheus/client_golang/prometheus"
+)
 
 type WatcherMetrics struct {
 	recordsRead               *prometheus.CounterVec
@@ -69,13 +73,45 @@ func NewWatcherMetrics(reg prometheus.Registerer) *WatcherMetrics {
 		),
 	}
 
+	// Collectors will be re-registered to registry if it's got reloaded
+	// Reuse the old collectors instead of panicking out.
 	if reg != nil {
-		reg.MustRegister(m.recordsRead)
-		reg.MustRegister(m.recordDecodeFails)
-		reg.MustRegister(m.droppedWriteNotifications)
-		reg.MustRegister(m.segmentRead)
-		reg.MustRegister(m.currentSegment)
-		reg.MustRegister(m.watchersRunning)
+		if err := reg.Register(m.recordsRead); err != nil {
+			are := &prometheus.AlreadyRegisteredError{}
+			if errors.As(err, are) {
+				m.recordsRead = are.ExistingCollector.(*prometheus.CounterVec)
+			}
+		}
+		if err := reg.Register(m.recordDecodeFails); err != nil {
+			are := &prometheus.AlreadyRegisteredError{}
+			if errors.As(err, are) {
+				m.recordDecodeFails = are.ExistingCollector.(*prometheus.CounterVec)
+			}
+		}
+		if err := reg.Register(m.droppedWriteNotifications); err != nil {
+			are := &prometheus.AlreadyRegisteredError{}
+			if errors.As(err, are) {
+				m.droppedWriteNotifications = are.ExistingCollector.(*prometheus.CounterVec)
+			}
+		}
+		if err := reg.Register(m.segmentRead); err != nil {
+			are := &prometheus.AlreadyRegisteredError{}
+			if errors.As(err, are) {
+				m.segmentRead = are.ExistingCollector.(*prometheus.CounterVec)
+			}
+		}
+		if err := reg.Register(m.currentSegment); err != nil {
+			are := &prometheus.AlreadyRegisteredError{}
+			if errors.As(err, are) {
+				m.currentSegment = are.ExistingCollector.(*prometheus.GaugeVec)
+			}
+		}
+		if err := reg.Register(m.watchersRunning); err != nil {
+			are := &prometheus.AlreadyRegisteredError{}
+			if errors.As(err, are) {
+				m.watchersRunning = are.ExistingCollector.(*prometheus.GaugeVec)
+			}
+		}
 	}
 
 	return m