diff --git a/ICSharpCode.Decompiler/IL/Transforms/TransformAssignment.cs b/ICSharpCode.Decompiler/IL/Transforms/TransformAssignment.cs
index c666467502..a24783d214 100644
--- a/ICSharpCode.Decompiler/IL/Transforms/TransformAssignment.cs
+++ b/ICSharpCode.Decompiler/IL/Transforms/TransformAssignment.cs
@@ -132,6 +132,9 @@ bool TransformInlineAssignmentStObjOrCall(Block block, int pos)
 			}
 			if (block.Instructions[nextPos] is StObj stobj)
 			{
+				// unaligned.stobj cannot be inlined in C#
+				if (stobj.UnalignedPrefix > 0)
+					return false;
 				if (!stobj.Value.MatchLdLoc(inst.Variable))
 					return false;
 				if (!SemanticHelper.IsPure(stobj.Target.Flags) || inst.Variable.IsUsedWithin(stobj.Target))