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af_backprop

various modifications to alphafold to allow backprop through the model

projects that use af_backprop

  • SMURF: End-to-end learning of multiple sequence alignments with differentiable Smith-Waterman
  • ColabDesign: Making Protein Design accessible to all via Google Colab!
  • af2rank: linking to instances of alphafold to create a generator/discriminator