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Add more predictions to EpitopePrediction #201

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iskandr opened this issue May 10, 2024 · 0 comments
Open

Add more predictions to EpitopePrediction #201

iskandr opened this issue May 10, 2024 · 0 comments

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@iskandr
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iskandr commented May 10, 2024

Possible groups of predictions (each mapping predictor name -> number):

  • mhc_affinity_ic50
  • mhc_affinity_score
  • mhc_affinity_percentile_rank
  • mhc_stability_hours
  • mhc_stability_score
  • mhc_stability_percentile_rank
  • antigen_processing_score
  • antigen_processing_percentile_rank
  • pmhc_presentation_score
  • pmhc_presentation_percentile_rank
  • immunogenicity_score
  • immunogenicity_percentile_rank

Also change wt_peptide_sequence to:

  • closest_reference_peptide_sequence_in_any_protein
  • closest_reference_peptide_sequence_in_same_protein

And calculate:

  • edit_distance_to_closest_reference_peptide_in_any_protein
  • edit_distance_to_closest_reference_peptide_in_same_protein
  • edit_distance_to_closest_reference_peptide_in_any_protein_PMBEC
  • edit_distance_to_closest_reference_peptide_in_same_protein_PMBEC

How to avoid duplicating every prediction for MT vs. WT-any vs. WT-same?

Possible API:

MHC affinity score:

epitope.predictions["mhc"]["affinity"]["score"]["NetMHCpan-4.1"]
epitope.predictions["mhc"]["affinity"]["score"]["MHCflurry-2.0"]
epitope.predictions["mhc"]["affinity"]["score"]["median"]
epitope.predictions["mhc"]["affinity"]["score"]["mean"]

Integrated Antigen Processing has one fewer level?

epitope.predictions["processing"]["score"]["MHCflurry-2.0"]
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