diff --git a/news/547.api_change b/news/547.api_change
new file mode 100644
index 000000000..00ded5ee8
--- /dev/null
+++ b/news/547.api_change
@@ -0,0 +1 @@
+Removed support for `OmegaConf.is_none(cfg, "key")`.  Please use `cfg.key is None` instead.
diff --git a/omegaconf/omegaconf.py b/omegaconf/omegaconf.py
index d23b2b15b..126108931 100644
--- a/omegaconf/omegaconf.py
+++ b/omegaconf/omegaconf.py
@@ -627,20 +627,6 @@ def is_optional(obj: Any, key: Optional[Union[int, str]] = None) -> bool:
         else:
             return True
 
-    # DEPRECATED: remove in 2.2
-    @staticmethod
-    def is_none(obj: Any, key: Optional[Union[int, DictKeyType]] = None) -> bool:
-        warnings.warn(
-            "`OmegaConf.is_none()` is deprecated, see https://github.com/omry/omegaconf/issues/547",
-            stacklevel=2,
-        )
-
-        if key is not None:
-            assert isinstance(obj, Container)
-            obj = obj._get_node(key)
-
-        return _is_none(obj, resolve=True, throw_on_resolution_failure=False)
-
     @staticmethod
     def is_interpolation(node: Any, key: Optional[Union[int, str]] = None) -> bool:
         if key is not None:
diff --git a/tests/test_matrix.py b/tests/test_matrix.py
index 5a2600bc0..c003950c2 100644
--- a/tests/test_matrix.py
+++ b/tests/test_matrix.py
@@ -49,8 +49,6 @@ def verify(
         assert cfg.get(key) == exp
 
     assert OmegaConf.is_missing(cfg, key) == missing
-    with warns(UserWarning):
-        assert OmegaConf.is_none(cfg, key) == none_public
     assert _is_optional(cfg, key) == opt
     assert OmegaConf.is_interpolation(cfg, key) == inter
 
diff --git a/tests/test_omegaconf.py b/tests/test_omegaconf.py
index 4a3517eea..2e37edc81 100644
--- a/tests/test_omegaconf.py
+++ b/tests/test_omegaconf.py
@@ -301,20 +301,12 @@ def test_is_none(fac: Any, is_none: bool) -> None:
 )
 def test_is_none_interpolation(cfg: Any, key: str, is_none: bool) -> None:
     cfg = OmegaConf.create(cfg)
-    with warns(UserWarning):
-        assert OmegaConf.is_none(cfg, key) == is_none
     check = _is_none(
         cfg._get_node(key), resolve=True, throw_on_resolution_failure=False
     )
     assert check == is_none
 
 
-def test_is_none_invalid_node() -> None:
-    cfg = OmegaConf.create({})
-    with warns(UserWarning):
-        assert OmegaConf.is_none(cfg, "invalid")
-
-
 @mark.parametrize(
     "fac",
     [