diff --git a/packages/runtime-core/__tests__/apiCreateApp.spec.ts b/packages/runtime-core/__tests__/apiCreateApp.spec.ts
index f6386339741..3e31cf8e750 100644
--- a/packages/runtime-core/__tests__/apiCreateApp.spec.ts
+++ b/packages/runtime-core/__tests__/apiCreateApp.spec.ts
@@ -8,6 +8,7 @@ import {
   nextTick,
   nodeOps,
   onMounted,
+  onScopeDispose,
   provide,
   ref,
   resolveComponent,
@@ -556,6 +557,26 @@ describe('api: createApp', () => {
     ).not.toHaveBeenWarned()
   })
 
+  test('should invoke onScopeDispose when the app unmount', () => {
+    const spy = vi.fn(() => {})
+    const root = nodeOps.createElement('div')
+
+    const app = createApp({
+      setup() {
+        return () => h('div')
+      },
+    })
+
+    app.runWithContext(() => {
+      onScopeDispose(spy)
+    })
+
+    app.mount(root)
+    app.unmount()
+
+    expect(spy).toHaveBeenCalledTimes(1)
+  })
+
   // #10005
   test('flush order edge case on nested createApp', async () => {
     const order: string[] = []
diff --git a/packages/runtime-core/src/apiCreateApp.ts b/packages/runtime-core/src/apiCreateApp.ts
index b3373dc8662..de6e6b7b277 100644
--- a/packages/runtime-core/src/apiCreateApp.ts
+++ b/packages/runtime-core/src/apiCreateApp.ts
@@ -1,3 +1,4 @@
+import { effectScope } from '@vue/reactivity'
 import {
   type Component,
   type ComponentInternalInstance,
@@ -28,6 +29,7 @@ import { installAppCompatProperties } from './compat/global'
 import type { NormalizedPropsOptions } from './componentProps'
 import type { ObjectEmitsOptions } from './componentEmits'
 import type { DefineComponent } from './apiDefineComponent'
+import type { EffectScope } from '@vue/reactivity'
 
 export interface App<HostElement = any> {
   version: string
@@ -70,6 +72,7 @@ export interface App<HostElement = any> {
   _container: HostElement | null
   _context: AppContext
   _instance: ComponentInternalInstance | null
+  _scope: EffectScope
 
   /**
    * v2 compat only
@@ -215,6 +218,7 @@ export function createAppAPI<HostElement>(
       rootProps = null
     }
 
+    const scope = effectScope(true)
     const context = createAppContext()
     const installedPlugins = new WeakSet()
 
@@ -227,6 +231,7 @@ export function createAppAPI<HostElement>(
       _container: null,
       _context: context,
       _instance: null,
+      _scope: scope,
 
       version,
 
@@ -371,6 +376,7 @@ export function createAppAPI<HostElement>(
 
       unmount() {
         if (isMounted) {
+          scope.stop()
           render(null, app._container)
           if (__DEV__ || __FEATURE_PROD_DEVTOOLS__) {
             app._instance = null
@@ -399,7 +405,7 @@ export function createAppAPI<HostElement>(
         const lastApp = currentApp
         currentApp = app
         try {
-          return fn()
+          return app._scope.run(fn)!
         } finally {
           currentApp = lastApp
         }