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@scbirlab

SCBIR Lab

Systems Chemical Biology of Infection and Resistance Laboratory

Logo of SCBIR lab

The SCBIR lab is based the Francis Crick Institute in London. We use large-scale genetics and chemical biology to study how pathogenic bacteria infect and evolve resistance to antibiotics.

Ultimately, we aim to enable antimicrobial therapies which exploit key weaknesses in the ability of pathogenic bacteria to infect and evolve resistance to antibiotics.

Our work focuses on these areas (click the links for more information):

Find out more about our research here!

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  1. hts-tools Public

    🏮 Parsing and analysing platereader absorbance and fluorescence data.

    Python 1

  2. schemist Public

    ⬢⬢⬢ Organizing and processing tables of chemical structures.

    Python 1

  3. yunta Public

    Forked from patrickbryant1/SpeedPPI

    🍐 Predicting protein-protein interactions and structures from multiple sequence alignments.

    Python 1

  4. crispio Public

    🌱 Designing CRISPRi experiments in bacteria

    Python

  5. lchemme Public

    🚄 Training and applying large chemistry models for embeddings.

    Python

  6. duvida Public

    🧐 Calculating exact and approximate confidence and information metrics for deep learning on general purpose and chemistry tasks.

    Python

Repositories

Showing 10 of 26 repositories
  • duvida Public

    🧐 Calculating exact and approximate confidence and information metrics for deep learning on general purpose and chemistry tasks.

    Python 0 MIT 0 0 0 Updated Apr 1, 2025
  • lchemme Public

    🚄 Training and applying large chemistry models for embeddings.

    Python 0 MIT 0 0 0 Updated Mar 24, 2025
  • crispio Public

    🌱 Designing CRISPRi experiments in bacteria

    Python 0 MIT 0 0 0 Updated Mar 13, 2025
  • schemist Public

    ⬢⬢⬢ Organizing and processing tables of chemical structures.

    Python 1 MIT 0 0 0 Updated Mar 4, 2025
  • carabiner Public

    🪨 Useful python utilities.

    Python 0 MIT 0 0 0 Updated Mar 1, 2025
  • nf-inspect Public

    🧬🔍 Nextflow pipeline to process demultiplexed Illumina paired-end FASTQ files from INSPECT experiments.

    Nextflow 0 MIT 0 0 0 Updated Feb 27, 2025
  • nf-sbrnaseq Public

    Nextflow pipeline to process demultiplexed Illumina paired-end FASTQ files from multiple bacterial samples into a gene x cell count table.

    Nextflow 0 MIT 0 0 0 Updated Feb 27, 2025
  • nf-crispriseq Public

    Calculate fitness from massive competition experiments using CRISPRi-seq.

    Nextflow 0 MIT 0 0 0 Updated Feb 25, 2025
  • ogilo Public

    ⛓️ Automating construction of oligo library sequences for oligo array synthesis.

    Python 0 MIT 0 0 0 Updated Feb 19, 2025
  • monte-barcode Public

    🔴🟢🔵⚫️ Generating sets of random DNA sequences optimized for use in high-throughput sequencing.

    Python 0 MIT 0 0 0 Updated Feb 19, 2025

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