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RTF
There are two versions of the "transient functions" so far:
- The "transient function" (TF) for immediate response.
- The "retarded transient function (RTF)" for delayed responses
Both functions are universal tools describing many time course from the systems biology field data amazingly well. D2D contains examples in the folder arFramework3\Examples\ToyModels\TransientFunction
.
The transient functions have a sustained and a transient fraction and can describe responses in upward and downward directions, i.e. activatory and inhibitory dynamics in the systems biology setting. Therefore, fitting involves testing both directions. Fitting both possibilitites is done by arFitTransient.m
.
For using arFitLHS
, arFits
had to be adapted in order to call arFitTransient
instead of arFit
. Moreover, reasonable bounds are required especially for the time-scales. This is done in DefaultLbUbTransient*
. The meaning of the parameters is determined in Initialize_FitTransient
. All these functions are in folder arFramework3\Examples\ToyModels\TransientFunction_library
.
- Installation and system requirements
- Setting up models
- First steps
- Advanced events and pre-equilibration
- Computation of integration-based prediction bands
- How is the architecture of the code and the most important commands?
- What are the most important fields of the global variable ar?
- What are the most important functions?
- Optimization algorithms available in the d2d-framework
- Objective function, likelhood and chi-square in the d2d framework
- How to set up priors?
- How to set up steady state constraints?
- How do I restart the solver upon a step input?
- How to deal with integrator tolerances?
- How to implement a bolus injection?
- How to implement washing and an injection?
- How to implement a moment ODE model?
- How to run PLE calculations on a Cluster?