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# Applications of Casanovo | ||
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De novo peptide sequencing has diverse applications in proteomics ranging from antibody sequencing to paleoproteomics. Here are some papers that use Casanovo for de novo sequencing in different domains: | ||
_De novo_ peptide sequencing has diverse applications in proteomics, ranging from antibody sequencing to paleoproteomics. Here are some papers that use Casanovo for _de novo_ sequencing in different domains: | ||
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- **[Cryo-EM reveals that cardiac IGLV6-derived AL fibrils can be polymorphic](https://doi.org/10.1101/2024.12.04.626857)** Casanovo is used to de novo sequence fibrils, i.e. antibody light chain aggregates. | ||
- **[Cryo-EM reveals that cardiac IGLV6-derived AL fibrils can be polymorphic](https://doi.org/10.1101/2024.12.04.626857)**: Casanovo is used to _de novo_ sequence fibrils, i.e. antibody light chain aggregates. | ||
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- **[Comprehensive evaluation of peptide de novo sequencing tools for monoclonal antibody assembly](https://doi.org/10.1093/bib/bbac542)** Casanovo is used to de novo sequence monoclonal antibodies and shown to outperform other de novo sequencing tools. | ||
- **[Comprehensive evaluation of peptide _de novo_ sequencing tools for monoclonal antibody assembly](https://doi.org/10.1093/bib/bbac542)**: Casanovo is used to _de novo_ sequence monoclonal antibodies and shown to outperform other _de novo_ sequencing tools. | ||
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- **[Giant genes are rare but implicated in cell wall degradation by predatory bacteria](https://doi.org/10.1101/2023.11.21.568195)** Casanovo is used to de novo sequence giant proteins with up to 85,804 amino acids in a metagenomic setting. | ||
- **[Giant genes are rare but implicated in cell wall degradation by predatory bacteria](https://doi.org/10.1101/2023.11.21.568195)**: Casanovo is used to _de novo_ sequence giant proteins with up to 85,804 amino acids in a metagenomic setting. | ||
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- **[De novo assembled databases enable species-specific protein-based stable isotope probing of microbiomes without prior knowledge of the community composition](https://doi.org/10.1101/2024.11.25.625156)** Casanovo is used to de novo sequence microbial peptides to enable species-specific protein-based stable isotope probing. | ||
- **[_De novo_ assembled databases enable species-specific protein-based stable isotope probing of microbiomes without prior knowledge of the community composition](https://doi.org/10.1101/2024.11.25.625156)**: Casanovo is used to _de novo_ sequence microbial peptides to enable species-specific protein-based stable isotope probing. | ||
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- **[Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases](https://doi.org/10.1101/2024.11.11.622451)** Casanovo is used to profile the sequence diversity of circulating monoclonal antibody repertoire. | ||
stable isotope probing. | ||
- **[Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases](https://doi.org/10.1101/2024.11.11.622451)**: Casanovo is used to profile the sequence diversity of circulating monoclonal antibody repertoire. |