Add support for specifyign a bridge adapter for more complete simulation of Dnase Hi-C. #24
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Change Points
Fixed a bug in ligation site creation
When Hi-C reads were created with HindIII (A^AGCTT), the ligation site should be AAGCTAGCTT as for as I know, but in sim3C, it was AAGCTAGCTAGCTT. So I fixed it.
Fixed an error that occurred when using the linear option
Errors sometimes occur when using the linear option. So I fixed it.
Set initial value of efficiency when -m dnase option is used
The initial value of efficiency was not specified when using -m dnase option, so it was set.
Fixed a bug in which read orientation was fixed when creating Hi-C reads
In sim3C, the orientation of the reads was fixed as shown in the figure below. But as for as I know, the orientation of the Hi-C reads is generally random. So I fixed it.
Added --bridge-adapter option
Added the function to insert a bridge adapter sequence when using the -m dnase option.
Added --sam option
Added the function to output SAM format files.