Illustrate membrane proteins

[eweitz]

This illustrates membrane proteins and their parts, adding cellular context to features in human protein diagrams.

Roughly 1/3 of human proteins are membrane proteins. Those are targets for > 1/2 of all drugs. Membrane proteins are also recalcitrant to protein structure determination. However, topological annotations -- i.e., which parts of the protein are extracellular, transmembrane, or cytoplasmic -- can highlight functionally relevant regions of the protein.

Previously, it was almost impossible to tell at a glance which proteins were found on the cell membrane. Now, this is visible at a glance by underlaying protein topology features behind other existing protein features. Topology features come from UniProt, and are now included in the bolus of data that populates the protein cache upon initializing gene leads ideogram.

Here's how it looks.

Before: LDLR

After: LDLR

Before: ACE2

After: ACE2